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As
Seen on 60 Minutes
- (CBS) Each
year, people spend more than $40 billion on products designed
to help them slim down. None of them seem to be working
very well. Now along comes hoodia. Never heard of it? Soon
it'll be tripping off your tongue, because hoodia is a natural
substance that literally takes your appetite away. It's
very different from diet stimulants like Ephedra and Phenfen
that are now banned because of dangerous
side effects. Hoodia doesn't stimulate at all. Scientists
say it fools the brain by making you think you're full,
even if you've eaten just a morsel.
Correspondent Lesley Stahl reports.
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Hoodia is a bitter-tasting cactus-like plant. 60 Minutes
was told that if it wanted to try hoodia, it would have
to go to Africa. Why? Because the only place in the world
where hoodia grows wild is in the Kalahari Desert of South
Africa. Nigel Crawhall, a linguist and interpreter, hired
an experienced tracker named Toppies Kruiper, a local aboriginal
Bushman, to help find it. The Bushmen were featured in the
movie 'The Gods Must Be Crazy." Kruiper led 60 Minutes
crews out into the desert. Stahl asked him if he ate hoodia.
"I really like to eat them when the new rains have
come," says Kruiper, speaking through the interpreter.
"Then they're really quite delicious." When we
located the plant, Kruiper cut off a stalk that looked like
a small spiky pickle, and removed the sharp spines. In the
interest of science, Stahl ate it. She described the taste
as "a little cucumbery in texture, but not bad."
So how did it work? Stahl says she had no after effects
– no funny taste in her mouth, no queasy stomach,
and no racing heart. She also wasn't hungry all day, even
when she would normally have a pang
around mealtime. And, she also had no desire to eat or drink
the entire day.
"I'd have to say it did work,"says Stahl.
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The
Truth about Hoodia
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- Deep
inside the African Kalahari desert grows an ugly cactus
called the Hoodia.
It thrives in extremely high temperatures, and takes
years to mature.
- The
San Bushmen of the Kalahari have been eating hoodia
for thousands of years, to stave off hunger during
long hunting trips.
- South
African scientists discovered hoodia contains a previously
unknown molecule, which has since been christened
P-57.
- The
license for P 57 was sold to a Cambridgeshire bio-pharmaceutical
company, Phytopharm, who in turn sold the rights to
P57 development and marketing rights to the giant
Pfizer Corporation.
- Phytopharm's
Dr Richard Dixey explains how P.57 actually works:
"There is a part of your brain, the hypothalamus.
Within that mid-brain there are nerve cells that sense
glucose sugar. When you eat, blood sugar goes up because
of the food, these cells start firing and now you
are full. What the Hoodia seems to contain is a molecule
that is about 10,000 times as active as glucose. It
goes to the mid-brain and actually makes those nerve
cells fire as if you were full. But you have not eaten.
Nor do you want to."
- Phytopharm's
Dr Richard Dixey organised the first animal trials
for Hoodia. Rats, a species that will eat literally
anything, stopped eating completely.
- When
the first human clinical trial was conducted, a morbidly
obese group of people were placed in a "phase
1 unit", a place as close to prison as it gets.
All the volunteers could do all day was read papers,
watch television, and eat. Half were given Hoodia,
half placebo. Fifteen days later, the Hoodia group
had reduced their calorie intake by 1000 a day. Given
the average daily diet is around 2200 calories; the
trial was a stunning success.
- A
synthetic prescription Hoodia drug from Phytopharm
will not be around for several years due to clinical
trials.
- While
many people feel the appetite suppressant kicking
in sometimes within 20 minutes of ingestion, it is
felt that the general population responds to hoodia
within 1 ñ 2 weeks of starting the program.
- Some
morbidly obese people (more than double their normal
weight), who describe themselves as eating machines
since childhood, say that although they felt the appetite
suppressant kicking in after 2 ñ 3 weeks, it took
a few weeks before they realized their interest in
food was significantly decreasing, thereby helping
to change life long eating habits.
.......................................................................................................
Hoodia
Side Effects
- Hoodia
will cause your brains to believe you are full. This
effect can last 24 hours
- San
tribesmen say that they also get abundant energy
- Hoodia
is said to have a feel-good aphrodisiac quality
felt mainly by men.
- San
tribesmen also say that Hoodia will cure hangovers
and upset stomachs
- There
are no cumulative side-effects
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